THP-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 658858-65-2

Molecular Weight: 454.55

Formula: C21H42O10

Chemical Name: 23-(oxan-2-yloxy)-3,6,9,12,15,18,21-heptaoxatricosan-1-ol

Smiles: OCCOCCOCCOCCOCCOCCOCCOCCOC1CCCCO1

InChiKey: BMBLURHCJAQZLN-UHFFFAOYSA-N

InChi: InChI=1S/C21H42O10/c22-4-6-23-7-8-24-9-10-25-11-12-26-13-14-27-15-16-28-17-18-29-19-20-31-21-3-1-2-5-30-21/h21-22H,1-20H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.