Lamin A/C (D230) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS7014-50, BS7014-100

Sizes: 50µl, 100µl

Swiss-Prot: P02545

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear disregulation and cell death.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Lamin A/C (D230) polyclonal antibody detects endogenous levels of Lamin A/C protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Lamin A/C (D230) at 1:500 dilution
Lane 1: AML-12 whole cell lysate (40ug)
Lane 2: C6 whole cell lysate (40ug)
Lane 3: Panc1 whole cell lysate (40ug)
Lane 4: H1792 whole cell lysate (40ug), Immunohistochemistry (IHC) analysis of Lamin A/C (D230) pAb in paraffin-embedded human lung carcinoma tissue.

Bioworld Molecular Weight: ~ 64, 73 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C

Immunogen: Synthetic peptide, corresponding to amino acids 231-280 of Human Lamin A.

Conjugate: Unconjugated

Modification: Unmodified