Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.

Product information

CAS Number: 69-93-2

Molecular Weight: 168.11

Formula: C5H4N4O3

Chemical Name: 2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione

Smiles: O=C1NC(=O)NC2NC(=O)NC1=2

InChiKey: LEHOTFFKMJEONL-UHFFFAOYSA-N

InChi: InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 1 mg/mL (5.95 mM; Need ultrasonic). H2O : 0.2 mg/mL (1.19 mM; ultrasonic and warming and heat to 37°C).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation. Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity.

In Vivo:

Uric acid (250 mg/kg; p.o.) ameliorates indomethacin-induced enteropathy. Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy.

Products are for research use only. Not for human use.