Since the late fourteenth century, European artists created an extensive body of images, in paintings, prints, drawings, sculptures, and other media, about the horrors of disease and death, as well as hope and salvation. This interdisciplinary study on disease in metaphysical context is the first general overview of plague art written from an art-historical standpoint. The book selects masterpieces created by Raphael, Titian, Tintoretto, Rubens, Van Dyck, and Poussin, and includes minor works dating from the fourteenth to twentieth centuries. It highlights the most important innovative artistic works that originated during the Renaissance and the Catholic Reformation. This study of the changing iconographic patterns and their iconological interpretations opens a window to the past.